Thursday, 21 March, 2019

Second person cured of HIV in major medical breakthrough

London patient second in world to be cleared of Aids virus – researchers London HIV Patient World's Second To Be Cleared Of AIDS Virus: Doctors
Celia Hoffman | 07 March, 2019, 03:24

Tests found no trace of the virus - which causes Aids - more than 18 months after the man came off the antiretroviral drugs he was using to manage the condition.

"Finding a way to eliminate the virus entirely is an urgent global priority, but is particularly hard because the virus integrates into the white blood cells of its host", said the study's lead author, Professor Ravindra Gupta from the University of Cambridge, who led the study while at UCL.

The researchers say it is too early to say the patient is "cured" of HIV.

Both the first patient to be cured of H.I.V., Timothy Ray Brown, who is now 52 and was cured in 2007, and the new patient, whom scientists refer to as the "London patient," were afflicted with forms of cancer and were given bone-marrow transplants meant to treat their cancers, not the H.I.V virus, according to The New York Times. He is still HIV-free.

Institutions involved in the case include Imperial College London, University College London, and Cambridge and Oxford University. The patient, who wishes to remain anonymous but is known as "the London patient", was diagnosed with HIV in 2003 and developed Hodgkin's lymphoma, a cancer of the white blood cells, in 2012.

In 2016, when he was very ill with cancer, doctors chose to seek a transplant match for him.

Both the London and Berlin patients received stem cell transplants from donors carrying a genetic mutation that prevents expression of an HIV receptor, known as CCR5. Researchers are reporting a second patient has lived 18 months after stopping HIV treatment without sign of the virus following a stem-cell transplant.

More news: School Of Rock Actor Arrested Four Times For Stealing Guitars

Timothy Brown, said to be the first person to "beat" HIV/Aids, was given two transplants and total body irradiation (radiotherapy) for leukaemia - a much more aggressive treatment. The procedure is expensive, complex and risky.

Ravindra Gupta notes that the donor's unusual resistance to HIV may not be the only reason the treatment cleared the London patient's infection.

The case was published online by the journal Nature and will be presented at an HIV conference in Seattle. The first recipient, Timothy Brown, gained fame as the so-called Berlin patient after transplants in 2007 and 2008 rid him of HIV.

"If you are saying that bone marrow transplants are now going to be a viable way to cure large numbers of people with HIV in a scalable way, the answer to that is absolutely not", says Dr. Anthony Fauci, director of the National Institutes of Health's National Institute of Allergy and Infectious Diseases.

Stem cell transplants typically are harsh procedures which start with radiation or chemotherapy to damage the body's existing immune system and make room for a new one. There are complications too.

"But this is not applicable to the millions of people who don't need a stem cell transplant". That patient had a leukemia that could be treated with a blood stem-cell transplant, and his transplant team used cells that carried a mutation that eliminates one of the proteins that HIV uses to attach to cells.

Dr. Gero Hutter, the German doctor who treated Brown, called the new case "great news" and "one piece in the HIV cure puzzle".

Recommended

  • Martha McSally Alleges Rape by Superior Officer in Air Force

    Martha McSally Alleges Rape by Superior Officer in Air Force

    McSally has been candid about previous abuse and harassment she has survived, telling the Wall Street Journal in 2018 that, as a teenager, she was emotionally manipulated into sex by a running coach two decades her senior.
    Seven family members among 23 killed

    Seven family members among 23 killed

    They've become one team, one fight. "And a big banner that read "#BEAUREGARDSTRONG" was hung on a fence at Beauregard High School. The youngest victim was Armando Hernandez, 6, family member Sara Crisp said. "Everybody knows everybody around here".
    Modric admits Madrid feel loss of Ronaldo

    Modric admits Madrid feel loss of Ronaldo

    There is a huge positive in the emergence of Vinicius Junior , who is carving out a reputation for himself in his debut campaign, but the Brazilian is still very much a raw talent.
  • Meghan Markle Made a Surprise On-Stage Appearance with Prince Harry

    Meghan Markle Made a Surprise On-Stage Appearance with Prince Harry

    Watch the sweet video below! It was to celebrate the 50th anniversary of the investiture of Prince Charles , her father-in-law. The duchess, 37, looked chic in a navy blazer, black sweater and skinny jeans, while her husband looked smart in a grey suit .
    Warriors, 76ers expected to express interest in Bogut

    Warriors, 76ers expected to express interest in Bogut

    Newhouse School of Public Communications at Syracuse University and joined ESPNChicago.com for its launch in April 2009. The 24-year-old Embiid is averaging 27.3 points and 13.5 rebounds in 54 games for the Sixers .
    It's been revealed that QuadrigaCX cold storage wallets are basically empty

    It's been revealed that QuadrigaCX cold storage wallets are basically empty

    However, EY's report also point to the fact that since April 2008, there has been no further activity or deposits to the wallet. The report also said that the Bitcoins in the Identified Bitcoin Cold Wallets were transferred out completely in April 2018.
  • Ex-Attorneys General Call For RCMP Probe Into SNC-Lavalin Affair

    Ex-Attorneys General Call For RCMP Probe Into SNC-Lavalin Affair

    The prime minister faced a barrage of questions in various public appearances outside of Ottawa on Wilson-Raybould's allegations. But earlier this month, she had resigned from Trudeau's cabinet; so has the latter's close confidant, Gerry Butts.
    'Captain Marvel' Review Round-up: Critics Divided Over New Marvel Film

    'Captain Marvel' Review Round-up: Critics Divided Over New Marvel Film

    But all that changes - finally! - with the introduction of a stand-alone female Marvel superhero. And, Lashana Lynch provides the film its heart and humanity as Carol's best friend and fellow U.
    Trump Welcomes NDSU Football Team With Fast Food Spread

    Trump Welcomes NDSU Football Team With Fast Food Spread

    The Bison Coach did not want this trip to be shown as a political message but that it was a bonding experience for the team. You'll never guess what was on the menu for the players to eat.
  • Kevin Jonas reveals one person in the family who hates Priyanka Chopra

    Nick's eldest brother Kevin Jonas shared how his daughter Valentina was angry with Priyanka for taking Nick away from her. The duo first made public appearance together at the Ambani bash when Nick visited India to meet the family.
    Auckland's high five for rugby league fans

    Auckland's high five for rugby league fans

    Rugby League Players' Association chief executive Ian Prendergast said: "It's fantastic that there will be significant global content in 2019".
    What Could Be Funnier Than the Baby Cheese Challenge?

    What Could Be Funnier Than the Baby Cheese Challenge?

    For some reason, it took off and within hours people were copying him and the so-called "cheese challenge" was born. Inspired followers have started posting videos of flying cheese and the babies' reaction.

Fox News Reportedly Buried Stormy Daniels Story Before Election to Help Trump Fox News Reportedly Buried Stormy Daniels Story Before Election to Help Trump Rupert Murdoch owns Fox News and has always been an ally of Trump. Fox news execs have said the report was not ready to publish. Trump and his legal team have called Cohen a liar.

Some Canadian radio stations have stopped playing Michael Jackson songs Some Canadian radio stations have stopped playing Michael Jackson songs Wade Robson and James Safechuck accused the pop star of sexually abusing them over several years when they were younger . Rival broadcaster NZME also will not be playing the late pop star's music.

Neymar hints at joining Real Madrid, Football News & Top Stories Neymar hints at joining Real Madrid, Football News & Top Stories Things happen at unexpected moments, nobody knows what will happen tomorrow, ' he added. "Nowadays I'm very happy [at PSG]". Ferrer admits that he saw signing Mbappé ahead of the reigning European champions as nearly impossible.

R. Kelly arrested for unpaid child support payments R. Kelly arrested for unpaid child support payments He said the women accusing him were all lying, at times crying and yelling during the interview . Kelly performs during The Buffet Tour at Allstate Arena on May 7, 2016, in Chicago, Illinois .

Crew from aborted Soyuz capsule set for ISS mission next week Crew from aborted Soyuz capsule set for ISS mission next week But it won't happen before 2023 - with the rocket, far more powerful than that used for the Dragon mission, still in development. A dummy named Ripley is onboard a SpaceX Falcon 9 rocket during liftoff Saturday at the Kennedy Space Center in Florida.

Nokia 9 PureView lands in the UK March 21st Nokia 9 PureView lands in the UK March 21st Leaving the internal hardware parts aside, the feature that makes Nokia 9 PureView stand out the most is its five camera-setup. You can also shoot RAW photos, film in 4K HDR, and if that is not enough, then you can use the 20 MP selfie camera .

R. Kelly Claims Parents Wanted Him to Have Sex with Teen Daughter R. Kelly Claims Parents Wanted Him to Have Sex with Teen Daughter Before the interview aired, King told Chicago's local CBS station that it was clear that Kelly "is in a lot of pain". Kelly deemed it "not professional" that artists such as John Legend and Lady Gaga have spoken out against him .

Game Of Thrones season 8: First full trailer Game Of Thrones season 8: First full trailer Here are a few predictions for Daenerys Targaryen heading into the final season of Game of Thrones . The trailer for the final season of Game of Thrones has finally been unveiled.

Around 80 protestors arrested during Stephon Clark march Around 80 protestors arrested during Stephon Clark march He says Clark had broken vehicle windows and a neighbor's sliding glass door and refused police orders to stop and show his hands. Sacramento Bee reporter Dale Kasler was covering the event when he was arrested and detained for about an hour.

Gerald Butts to give PMO version of events in SNC-Lavalin affair Gerald Butts to give PMO version of events in SNC-Lavalin affair Asked about her departure, Finance Minister Bill Morneau began by observing that Wilson-Raybould and Philpott are close friends. Prime Minister Justin Trudeau has cancelled his trip to Regina scheduled for Tuesday afternoon.

Bombshells From R. Kelly's First Interview Since Sexual Abuse Charges Bombshells From R. Kelly's First Interview Since Sexual Abuse Charges Kelly and have fought to gain contact with their daughter. "They're old rumours, new rumours, future rumours". Clary's parents have repeatedly spoken out in the media and in the docu-series against R.

Tottenham find their stubborn streak as impenetrable white wall denies hosts Dortmund Tottenham find their stubborn streak as impenetrable white wall denies hosts Dortmund For me, after five years, it was the first time that we're going to face this situation and for the players and team this was new. Substitutes: Bruun Larsen (5), Pulisic (6), Delaney (5). "It was a massive game for us, very tough, but I feel very proud".

Police chiefs meet the Home Secretary over rising knife crime Police chiefs meet the Home Secretary over rising knife crime On Saturday night, 17-year-old Yousef Ghaleb Makki was stabbed to death in Hale Barns, near Altrincham, in Greater Manchester. Officers will conduct extra patrols, police will visit schools, and test purchases will be made at stores.

Kelly Denies Sexual Abuse Allegations in First Interview Kelly Denies Sexual Abuse Allegations in First Interview That's exactly what they're doing. "To make all of this stuff that's going on now, feel real to people", he exclaimed. He addressed Gaga in particular in his interview with King. "You know, John Legend has called you a serial rapist".

Ian Rapoport: Broncos among teams 'most intrigued' about possible Antonio Brown trade Ian Rapoport: Broncos among teams 'most intrigued' about possible Antonio Brown trade The Oakland Raiders , Tennessee Titans , and Washington Redskins were previously identified as interested parties. Now, according to Rapoport , the Jets and Cardinals are out, but three "new teams" threw their hat into the ring.