Researchers at the Van Andel Research Institute, in MI, looked at data on 1.7 million people over half a century.
"Our studies suggest that the appendix might be a tissue site that plays a role in the early events or initiation of Parkinson's disease". These aggregations are called Lewy bodies, and they're made up largely of a protein called alpha synuclein.
"If it were to enter the brain, it can seed and spread from there and have neurotoxic effects that could eventually lead to Parkinson's disease", she said. This builds on previous research indicating that, for some, Parkinson's starts in the gut.
Study coauthor Viviane Labrie, an assistant professor at the Van Andel Research Institute in MI, doesn't go quite as far, telling CNN the disease is a multisystem disorder, "so there's likely to be many sites of origin in terms of where Parkinson's disease starts, the [gastrointestinal tract] being one of them".
Knowing that people with Parkinson's also suffer from gastrointestinal disorders like constipation at least 10 years before the disease's better known symptoms like tremors, stiffness, and poor balance appear, researchers chose to take a closer look at the appendix and its potential role. There have even been promising signs that Parkinson's may be on the ever-growing list of conditions treatable by that most disgusting of miracle remedies, fecal transplants.
"Despite having a reputation as largely unnecessary, the appendix actually plays a major part in our immune systems, in regulating the makeup of our gut bacteria and now, as shown by our work, in Parkinson's disease", senior author Viviane Labrie from Van Andel Research Institute in MI told The Guardian. Labrie said that the appendix was just one possible place for the disease to start, but there are likely other origin points. And while the relationship between the appendix and Parkinson's is unknown, it may be that the appendix is a source of seeding-competent aggregates of alpha-synuclein which could migrate into the central nervous system through the vagal nerve, she added. He said he found the study results convincing.
In the Swedish registry, the researchers identified 551,647 people who had an appendectomy, matching each person to two control individuals who didn't have an appendectomy. All told, it comprises 92 million person-years of data. They imaged 48 appendixes taken from people without Parkinson's.
Commenting on the study, Claire Bale, Head of Research at Parkinson's United Kingdom, said: "The finding that removing the appendix early in life can reduce risk of Parkinson's suggests that it may play a contributing role in the loss of brain cells".
Alpha-synuclein is known for its ability to move around the body.
That meant that Parkinson's risk had dropped by 19.3 percent among those who had had their appendix removed. She explained that drug therapies could target this finding to prevent Parkinson's disease.
Their study was published Wednesday in the journal Science Translational Medicine.
The proteins themselves aren't the sole culprit behind the disease, though. It's only in the rare cases that they escape to the brain that Parkinson's occurs.
About one in 40 Britons develops Parkinson's, a condition in which the brain becomes increasingly degraded.
More research is needed to clarify that connection between the microbiome, the appendix and Parkinson's, but Labrie suggested that the immune system may play an important role. It's another piece of evidence that an environmental trigger of some sort - perhaps pesticides - helps to kick off the disease, thought what that might be is unknown.
The find gives Parkinson's researchers a new focus for their work, and it also hints at a new path for treatments. Potentially, the protein can travel up the vagus nerve connecting the gastrointestinal tract and the brain.
This research by Researchvector covers the current market size of the Protein Powders along with the growth rate over the years. Detailed Overview of Global Non-Protein Nitrogen in Feed market helps deliver clients and businesses making strategies.
According to another report by the, these two chemicals alone are used in over 3,500 popular sunscreen products worldwide. It targets "reef-toxic" sunscreens, which are those that contain one of 10 harmful chemicals, including oxybenzone .
When a Mexican mother gives birth in the United States of America , that child is automatically an AMERICAN citizen. By the time the issue reached the Supreme Court, it was without its most conservative justice - Antonin Scalia.
In their recent overseas tour to England, India suffered a 1-4 drubbing while earlier this year they lost 1-2 in South Africa. May be one or two in England. "I think the selector has already addressed this if I'm not wrong", he said.
And, true enough, the onstage announcement showed off Barbarian, Crusader, Demon Hunter, Necormancer, Wizard and Monk classes. WoW Classic has been a hotly anticipated new release from Blizzard, which just got a massive update at BlizzCon 2018 .
Personally I can not see Apple changing this just because the United Kingdom government wants them to. Apple devices have been fitted with Near Field Communication chips, as they are known, since 2014.
The incident came just a day after All Nippon Airways revealed a hung-over pilot had caused multiple flight delays. JAL issued an apology, promising it will "implement immediate actions to prevent any future occurrence".
Woodward will replace Jeff Banister, who was sacked by the Rangers in September after five years as Texas' head man. After his playing days, Woodward worked for the Mariners as a minor-league infield coordinator and infield coach.
In 2010, Barack Obama sent 1,200 National Guardsmen to the border for 15 months, as part of a mission he called Operation Phalanx. Claims have spiked in recent years, and there is now a backlog of more than 800,000 cases pending in immigration court.
Ellen DeGeneres surprises Top Chefs Fatima Ali with $50k gift
Last month, Ali revealed that her cancer had returned "with a vengeance" and doctors told her she had about a year left to live. The Top Chef contestant said she accomplished one of her first goals when she finally met DeGeneres, reported PEOPLE magazine.
Willie Taggart still coy about starting QB for NC State
Florida State is 3-1-1 with the over in its last five road games and 5-1-1 with the over in its last seven against a winning team. State history behind Torry Holt's 255 in 1998. "The pass game fundamentals (on defense) have to improve", Doeren said.
Two Hepatitis Related Deaths Reported In Franklin County
The Franklin County Health Department says both had underlying medical conditions that made their hepatitis A infections worse. Franklin County has a total of 28 cases of hepatitis A, and these are the first two deaths for the county.
Prince Charles, Camilla in Ghana on African trip
On Saturday, November 3, the British Royal will call on the Asantehene Otumfour Osei Tutu II at the Manhyia palace. But we are in the happier period now. "It's a relationship that we value", Nana Akufo-Addo said.
How do Leicester City recover from helicopter tragedy?
Goal senior editors Miles Chambers and Jim Knight discuss the tragic incident ahead of Saturday's game against Cardiff City. Vichai bought the club in 2010 and many in the team have expressed their admiration of him and their sorrow at his death.
Time to grow a Mo
It's the annual event in which men are encouraged to grow out their upper lip hair to raise funds and awareness for men's health. Growing a moustache was what kickstarted Movember back in 2003.
Current Trend:: Aurora Cannabis Inc., (NYSE: ACB)
Year to date is -30.77%, -10.34% over the last quarter, -42.58% for the past six months and -60.14% over the last 12 months. Narrowing in a bit closer, the 5 month price index is 1.16390, the 3 month is 1.35732, and the 1 month is now 0.78596.
Oil, gas deposits discovered in Zim
Zimbabwean President Emmerson Mnangagwa on Thursday announced the discovery of oil and gas deposits in Muzarabani, in the Mashonaland Central province.