Tuesday, 23 October, 2018

HPV Vaccine Approved For Adults Up To 45

Woman receiving the HPV vaccine Image zoom
Celia Hoffman | 11 October, 2018, 06:57

The Food and Drug Administration has approved an HPV vaccine for men and women from the ages of 27 to 45, potentially protecting another generation of people from the cancer-causing virus.

Gardasil 9 (HPV 9-valent Vaccine, Recombinant), a vaccine for the prevention of HPV, has been approved by the FDA for use in males and females aged 9 through 45 years.

The effectiveness of Gardasil is relevant to Gardasil 9 since the vaccines are manufactured similarly and cover four of the same HPV types. This is huge news, as the maximum age of people who can now get the vaccine has almost doubled.

"In theory, there's no reason that the vaccine would not also provide some protection for people over 45", said Jaffy, a UW Medicine family medicine physician.

Regarding prevention and treatment, Brown recommends the HPV vaccine, widely provided to everyone-regardless of sex, gender, or sexual orientation-before sexual debut, and genital wart treatment.

The vaccine-previously approved for use in females and males aged 9 through 26 years-prevents certain cancers and diseases caused by 9 human papillomavirus (HPV) types, including cervical, vulvar, vaginal, and anal cancers in women, and anal cancer in men.

HPV can lead to certain types of cancers, particularly cervical in women and oral HPV in men. That's because even though many adults have been exposed to some types of HPV, most have not been exposed to all nine types covered by the vaccine.

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Dr. Ramondetta noted that tumors affecting part of the throat — called oropharyngeal cancers — caused by HPV are rising, particularly in men.

To determine patients' current and future risk, "I ask about sexual history", Jaffy said. "People who have been in a monogamous relationship for an extended period are less likely to be exposed to a new virus".

She added: "There is a whole generation of people we were missing who didnt know about it. Doctors werent good at talking about it". In fact, a body weakened by one battle with HPV might benefit greatly from the vaccine, Jaffy said - one reason that expanding eligibility makes sense.

The approval was constructed from a study among women ages 27-45, showing that the previous version of the vaccine had great impact preventing the persistent infection of HPV, genital warts, vaginal and vulvar precancers, cervical cancer, and cervical precancers related to the types of virus covered by the vaccine.

The FDA change will take time to be fully implemented, Jaffy explained. "It could take six to 12 months to go full force", he suggested.

For the study, the team investigated almost 600 men who have sex with men, or MSM, and transgender women in Lima, Peru. There now is a shortage of Shingrix, the vaccine to protect people 50 and older against the painful nerve condition of shingles.

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